Med. Klinik I: Gastroenterologie und Hepatologie, Pneumologie und Allergologie, Endokrinologie und Diabetologie sowie Ernährungsmedizin -
Prof. Dr. Stefan Zeuzem

>

Expertise

• Suche nach neuen immunmodulatorischen Pharmaka in der Therapie chronisch entzündlicher Darmkrankheiten
  
• Sekundäre Prävention des kolorektalen Karzinoms
  
• Antikarzinogene Wirkungen von sekundären Pflanzenstoffen (Prebiotika, Polyphenole)
  
• Therapie der chronischen Hepatitis C
  
  

>

Methoden und Geräte

• 2D-Gelelektrophorese
  
• semi-quantitative PCR (Pico-Green), RNase-Verdauungsschutzanalyse, DNA-Sequenzierung, Klonierung, Transfektion/Transformation
  
• Immunhistochemie
  
• HPLC
  
• Radioisotopenanalysator
  
• Infrarotspektrometrie
  
• Exhaled hydrogen Monitor
  - C13-Atemtests, H2-Atemtests
  
• FACS
  
• Patchclamp-Untersuchungen, Calcium-Imaging (an Einzelzellen und organotypischen Slices)
  
• Tierexperimentelle Methoden:
  - Colitis-Modelle (TNBS, DSS, IL-2)
  - Mukoviszidose-Modell (CFTR-Knockout-Maus)
  
  

>

Mitarbeiter

• PD Dr. Gerlinde Teuber (Klinische Studien, Analytik)

>

Publikationen

• Bott C, Rudolph MW, Schirrmacher S, Skalsky B, Petereit H-U, Langguth P, Dressman JB, Stein J. In vivo evaluation of a novel pH- and time-based multi-unit drug deilivery system. Aliment Pharmacol Ther (submitted).
  
• Schröder O, Blumenstein I, Schulte-Bockholt A, Stein J. Combining infliximab and methotrexate in fistulising Crohn's disease resistant or intolerant to azathioprine. Aliment Pharmacol Ther 2004; 19:295-301.
  
• Teuber G, Pascu M, Berg T, Lafrenz M, Pausch J, Kullmann F, Ramadori G, Arnold R, Weidenbach H, Musch E, Junge U, Wiedmann KH, Herrmann E, Zankel M, Zeuzem S. Randomized, controlled trial with IFN-alpha combined with ribavirin with and without amantadine sulphate in non-responders with chronic hepatitis C. J Hepatol 2003; 39:606-613.
  
• Schröder O, Stein J. Low dose methotrexate in inflammatory bowel disease: current status and future directions. Am J Gastroenterol 2003; 98:530-537.
  
• Jordan A, Stein J. Effect of an omega-3 fatty acid containing lipid emulsion alone and in combination with 5-fluorouracil (5-FU) on growth of the colon cancer cell line Caco-2. Eur J Nutr 2003; 42:324-331.
  
• Wolter F, Turchanowa L, Stein J. Resveratrol-induced modification of polyamine metabolism is accompanied by induction of c-Fos. Carcinogenesis 2003; 24:469-474.
  
• Trojan J, Povse N, Schröder O, Stein J. A new immunological test strip device for the rapid, qualitative detection of faecal occult blood. Z Gastroenterol 2002; 40:921-924.
  
• Gaschott T, Steinmeyer A, Steinhilber D, Stein J. ZK 156718, a low calcemic, antiproliferative, and prodifferentiating vitamin D analog. Biochem Biophys Res Commun. 2002; 290:504-509.
  
• Wächtershauser A, Akoglu B, Stein J. HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2. Carcinogenesis 2001; 22:1061-1067.
  
• Teuber G, Berg T, Naumann U, Raedle J, Brinkmann S, Hopf U, Zeuzem S. Randomized, placebo-controlled, double-blind trial with interferon-alpha with and without amantadine sulphate in primary interferon-alpha nonresponders with chronic hepatitis C. J Viral Hepat 2001; 8:276-283.
  
• Gaschott T, Wächtershauser A, Steinhilber D, Stein J. 1,25-Dihydroxycholecalciferol enhances butyrate-induced p21(Waf1/Cip1) expression. Biochem Biophys Res Commun. 2001; 283: 80-85.
  
• Sarrazin C, Teuber G, Kokka R, Rabenau H, Zeuzem S. Detection of residual hepatitis C virus RNA by transcription-mediated amplification in patients with complete virologic response according to polymerase chain reaction-based assays. Hepatology 2000; 32:818-23.