Klinik für Neurologie -
Prof. Dr. G. Auburger

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Expertise

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Methoden und Geräte

• Sequenz- / Genotyp-facility mit ABI377 und ABI5700Taqman
• Zellkultur-facility mit Axiovert200M und in-vivo-imaging
• Recombinant mouse facility mit Verhaltenstests
  
  

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Publikationen

• Gispert S, Twells R, Orozco G, Brice A, Weber J, Heredero L, Scheufler K, Riley B, Allotey R, Nothers C, Hillermann R, Lunkes A, Khati C, Stevanin G, Hernandez A, Margariño C, Klockgether T, Durr A, Chneiweiss H, Enczmann J, Farrall M, Beckmann J, Mullan M, Wernet P, Agid Y, Freund H-J, Williamson R, Auburger G§, Chamberlain S§ (1993) Chromosomal assignment of the second (Cuban) locus for autosomal dominant cerebellar ataxia (SCA2) to human chromosome 12q23-24.1. Nature Genetics, 4:295-299.
  
  
• Pulst S, Nechiporuk A, Nechiporuk T, Gispert S, Chen X, Lopes-Cendes I, Pearlman S, Starkman S, Orozco G, Lunkes A, de Jong P, Rouleau G, Auburger G, Korenberg JR, Figueroa C, Sahba S (1996) Moderate expansion of a normally biallelic trinucleotide repeat in Spinocerebellar ataxia 2. Nature Genetics 14:269-276.
  
  
• Leube B, Rudnicki D, Ratzlaff T, Kessler KR, Benecke R und Auburger G (1996) Idiopathic torsion dystonia: assignment of a gene to chromosome 18p in a German family with adult onset, autosomal dominant inheritance and purely focal distribution. Hum Mol Genet 5:1673-1677.
  
  
• Leroy E, Boyer R, Auburger G, Leube B, Ulm G, Mezey E, Harta G, Brownstein MJ, Jonnalagada S, Chernova T, Dehejia A, Lavedan C, Gasser T, Steinbach PJ, Wilkinson KD, Polymeropoulos MH (1998) A mutation in the Ubiquitin-hydrolase L1 gene in a family with Parkinson’s disease suggests a role for the ubiquitin pathway in neurodegenerative disorders. Nature 395:451-2.
  
  
• Paternotte C, Rudnicki D, Fizames C, Davoine C-S, Mavel D, Durr A, Samson D, Marquette C, Muselet D, Vega-Czarny N, Drouot N, Voit T, Fontaine B, Gyapay G, Auburger G, Weissenbach J, Hazan J (1998) Critical assessment of whole genome mapping data in the refined familial spastic paraplegia interval on chromosome 14q. Genome Res, 8:1216-1227.
  
  
• Alexander C, Votruba M, Pesch UEA, Thiselton DL, Mayer S, Moore A, Rodriguez M, Kellner U, Leo-Kottler B, Auburger G, Bhattacharya SS, Wissinger B (2000) A gene encoding a dynamin-related GTPase is mutated in autosomal dominant optic atrophy (OPA1) linked to chromosome 3q28. Nature Genetics 26:211-5.
  
  
• Gispert S, Del Turco D, Garrett L, Chen A, Bernard D, Hamm-Clement J, Korf HW, Deller T, Braak H, Auburger G§, Nussbaum RL§ (2003) Transgenic mice expressing mutant A53T human alpha synuclein show neuronal dysfunction in the absence of aggregate formation. Mol Cell Neurosci, 24:419-29.
  
  
• Valente EM, Abou-Sleiman PM, Caputo V, Muquit MMK, Harvey K, Gispert S, Ali Z, Del Turco D, Bentivoglio AR, Healy DG, Albanese A, Nussbaum R, Gonzalez-Maldonado R, Deller T, Salvi S, Cortelli P, Gilks WP, Latchman DS, Harvey RJ, Dallapiccola B, Auburger G§, Wood NW§ (2004) Hereditary early-onset Parkinson’s disease is caused by mutations in PINK1. Science, 304(5674):1158-60.
  
  
• Lee HY, Xu Y, Huang Y, Ahn AH, Auburger GW, Pandolfo M, Kwieciski H, Grimes DA, Lang AE, Nielsen JE, Averyanov Y, Servidei S, Friedman A, van Bogaert P, Abramovic MJ, Bruno MK, Sorensen BF, Tang L, Fu YH, Ptacek LJ (2004) The gene for paroxysmal non-kinesigenic dyskinesia encodes an enzyme in a stress response pathway. Hum Mol Genet, 13 (24):3161-70.
  
  
• Cabin DE, Gispert S, Murphy D, Auburger/ G/, Myers R, Nussbaum RL (2005) Exacerbated synucleinopathy in mice expressing A53T SNCA on a Snca null background. Neurobiol Aging, 26:25-35.
  
  

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Mitarbeiter:

• S. Gispert PhD
• Lastres, PhD
• H.H. Höpken, PhD
• F. Ricciardi
• B. Meseck-Selchow
• Mekhman Azizov
• Marina Talamini
• J.-S. Kang MD
• Wirjatijasa MD
• F. Eich Dipl. Biol.
• D. Nonis Dipl. Biol.
• S. van de Loo
• Alexander Kurz, Dipl. Biol.
  
  

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ZAFES-Ansprechpartner:

• Dr. med. Matthias Lorenz
  E-Mail: m.lorenz@zafes.de