Institut für Gastroenterologie und Hepatologie -
Prof. Dr. Stefan Zeuzem

Expertise

Suche nach neuen immunmodulatorischen Pharmaka in der Therapie chronisch entzündlicher Darmkrankheiten
Sekundäre Prävention des kolorektalen Karzinoms
Antikarzinogene Wirkungen von sekundären Pflanzenstoffen (Prebiotika, Polyphenole)
Therapie der chronischen Hepatitis C

Methoden und Geräte

2D-Gelelektrophorese
semi-quantitative PCR (Pico-Green), RNase-Verdauungsschutzanalyse, DNA-Sequenzierung, Klonierung, Transfektion/Transformation
Immunhistochemie
HPLC
Radioisotopenanalysator
Infrarotspektrometrie
Exhaled hydrogen Monitor
- C13-Atemtests, H2-Atemtests
FACS
Patchclamp-Untersuchungen, Calcium-Imaging (an Einzelzellen und organotypischen Slices)
Tierexperimentelle Methoden:
- Colitis-Modelle (TNBS, DSS, IL-2)
- Mukoviszidose-Modell (CFTR-Knockout-Maus)

Publikationen

Bott C, Rudolph MW, Schirrmacher S, Skalsky B, Petereit H-U, Langguth P, Dressman JB, Stein J. In vivo evaluation of a novel pH- and time-based multi-unit drug deilivery system. Aliment Pharmacol Ther (submitted).
Schröder O, Blumenstein I, Schulte-Bockholt A, Stein J. Combining infliximab and methotrexate in fistulising Crohn's disease resistant or intolerant to azathioprine. Aliment Pharmacol Ther 2004 Feb; 19(3): 295-301.
Teuber G, Pascu M, Berg T, Lafrenz M, Pausch J, Kullmann F, Ramadori G, Arnold R, Weidenbach H, Musch E, Junge U, Wiedmann KH, Herrmann E, Zankel M, Zeuzem S. Randomized, controlled trial with IFN-alpha combined with ribavirin with and without amantadine sulphate in non-responders with chronic hepatitis C. J Hepatol 2003 Oct; 39(4): 606-13.
Schröder O, Stein J. Low dose methotrexate in inflammatory bowel disease: current status and future directions. Am J Gastroenterol 2003 Mar; 98(3): 530-7.
Jordan A, Stein J. Effect of an omega-3 fatty acid containing lipid emulsion alone and in combination with 5-fluorouracil (5-FU) on growth of the colon cancer cell line Caco-2. Eur J Nutr. 2003 Dec; 42(6): 324-31.
Wolter F, Turchanowa L, Stein J. Resveratrol-induced modification of polyamine metabolism is accompanied by induction of c-Fos. Carcinogenesis. 2003 Mar; 24(3): 469-74.
Trojan J, Povse N, Schröder O, Stein J. A new immunological test strip device for the rapid, qualitative detection of faecal occult blood. Z Gastroenterol 2002 Nov; 40(11): 921-4.
Gaschott T, Steinmeyer A, Steinhilber D, Stein J. ZK 156718, a low calcemic, antiproliferative, and prodifferentiating vitamin D analog. Biochem Biophys Res Commun. 2002 Jan 11; 290(1): 504-9.
Wächtershauser A, Akoglu B, Stein J. HMG-CoA reductase inhibitor mevastatin enhances the growth inhibitory effect of butyrate in the colorectal carcinoma cell line Caco-2. Carcinogenesis. 2001 Jul; 22(7): 1061-7.
Teuber G, Berg T, Naumann U, Raedle J, Brinkmann S, Hopf U, Zeuzem S. Randomized, placebo-controlled, double-blind trial with interferon-alpha with and without amantadine sulphate in primary interferon-alpha nonresponders with chronic hepatitis C. J Viral Hepat 2001 Jul; 8(4): 276-83.
Gaschott T, Wächtershauser A, Steinhilber D, Stein J. 1,25-Dihydroxycholecalciferol enhances butyrate-induced p21(Waf1/Cip1) expression. Biochem Biophys Res Commun. 2001 Apr 27; 283(1): 80-5.
Sarrazin C, Teuber G, Kokka R, Rabenau H, Zeuzem S. Detection of residual hepatitis C virus RNA by transcription-mediated amplification in patients with complete virologic response according to polymerase chain reaction-based assays. Hepatology 2000 Oct; 32(4 Pt 1): 818-23.

Mitarbeiter:

Prof. Dr. med. Dr. oec. troph. Jürgen Stein (Analytik, Klinische Studien, Molekular- und Zellbiologie, Klinische Pharmakologie)
PD Dr. med. Gerlinde Teuber (Klinische Studien, Analytik)

ZAFES-Ansprechpartner: