Klinik für Neurologie -
Prof. Dr. med. M. Sitzer

Expertise

Atherosklerose (Mechanismen der Destabilisierung, Progression, HIV als Risikofaktor, Langzeitprognose intra- und extrakranieller Stentimplantationen)
Schlaganfall (Bedeutung molekularer Marker, Prävention der Post-Stroke-Depression)
Zerebrale Mikroangiopathie (Autoregulationsstudien, Wirkung von Statinen, Schlaganfall-Skalen)
Neurologische Ultraschalldiagnostik (Charakterisierung des Vertebralissystems, Echogenität der Substantia nigra)
Planung und Leitung Multizentrischer Klinische Studien (PREDIS)

Methoden und Geräte

Ultraschalllabor (ECD, TCD, Duplex, TCCD)
Funktionelle Ultraschalldiagnostik (Mikroemboliedetektion, Echovist-TCD, multimodale Autoregulationsmessung)

Publikationen

Trostdorf F, Sitzer M. Symptomatic carotid artery stenosis: heterogeneity of destabilizing mechanisms? Stroke. 2003 Jun;34(6):e41; author reply e41.
Markus HS, Sitzer M, Carrington D, Mendall MA, Steinmetz H. Chlamydia pneumoniae infection and early asymptomatic carotid atherosclerotic. Circulation 1999;100:832-837.
Sitzer M, Steckel D, Buehler A, Puac D, Markus H, Steinmetz H. Internal carotid artery rotative angle of origin - a novel risk factor for early carotid atherosclerosis. Stroke 2003;34:950-955.
Jerrad-Dunne P, Sitzer M, Buehler A, von Kegler S, Markus H. A promoter polymorphism of the interleukin-6 promoter polymorphism modulates the effects of heavy alcohol consumption on early carotid atherosclerosis. The Carotid Atherosclerosis Progression Study (CAPS). Stroke 2003;34:402-407.
Jerrad-Dunne P, Markus H, Steckel DA, Buehler A, von Kegler S, Risley P, Sitzer M. Early carotid atherosclerosis and family history of vascular disease: specific effects on arterial sites have implications for genetic studies. Arteriosclerosis, Thrombosis and Vascular Biology 2003;23:302-306.
Risley P, Jerrad-Dunne P, Sitzer M, Buehler A, von Kegler S, Markus H. Promoter polymorphism in the endotoxin receptor (CD14) is associated with increased carotid atherosclerosis only in smokers: the Carotid Atherosclerosis Progression Study (CAPS). Stroke 2003;34:600-604.
Dietz A, Berkefeld J, Schmitz-Rixen T, Zanella FE, Steinmetz H, Sitzer M,. Long-term follow up of patients after endovascular treatment of high-grade internal carotid artery stenosis using primary stent placement and distal ballon protection. Stroke 2001;32:1855-1859.
du Mesnil de Rochemont R, Turowski B, Buchkremer M, Sitzer M, Zanella F, Berkefeld J Safety and efficacy of undersized stents for recurrent symptomatic high-grade intracranial stenoses – initial experience. Radiology 2004 (in press).
Lorenz MW, von Kegler S, Steinmetz H, Markus HS, Sitzer M. Carotid intima-media thickening indicates a higher vascular risk across a wide age range: prospective data from the Carotid Atherosclerosis Progression Study (CAPS). Stroke. 2006 Jan;37(1):87-92
Kahles T, Foerch C, Sitzer M, Schroeter M, Steinmetz H, Rami A, Neumann-Haefelin T. Tissue plasminogen activator mediated blood-brain barrier damage in transient focal cerebral ischemia in rats: relevance of interactions between thrombotic material and thrombolytic agent. Vascul Pharmacol. 2005 Oct;43(4):254-9
Foerch C, Curdt I, Yan B, Dvorak F, Hermans M, Berkefeld J, Raabe A, Neumann-Haefelin T, Steinmetz H, Sitzer M. Serum glial fibrillary acidic protein as a biomarker for intracerebral haemorrhage in patients with acute stroke. J Neurol Neurosurg Psychiatry. 2006 Feb;77(2):181-4
Foerch C, Misselwitz B, Sitzer M, Berger K, Steinmetz H, Neumann-Haefelin T; Arbeitsgruppe Schlaganfall Hessen. Difference in recognition of right and left hemispheric stroke. Lancet. 2005 Jul 30-Aug 5;366(9483):392-3.
Foerch C, Singer OC, Neumann-Haefelin T, du Mesnil de Rochemont R, Steinmetz H, Sitzer M. Evaluation of serum S100B as a surrogate marker for long-term outcome and infarct volume in acute middle cerebral artery infarction. Arch Neurol. 2005 Jul;62(7):1130-4.
Trostdorf F, Buchkremer M, Harmjanz A, Kablau M, Jander S, Geiger K, Schmitz-Rixen T, Steinmetz H, Sitzer M. Fibrous cap thickness and smooth muscle cell apoptosis in high-grade carotid artery stenosis. Eur J Vasc Endovasc Surg. 2005 May;29(5):528-35.
Bevan S, Porteous L, Sitzer M, Markus HS. Phosphodiesterase 4D gene, ischemic stroke, and asymptomatic carotid atherosclerosis. Stroke. 2005 May;36(5):949-53
Jerrard-Dunne P, Sitzer M, Risley P, Buehler A, von Kegler S, Markus HS. Inflammatory gene load is associated with enhanced inflammation and early carotid atherosclerosis in smokers. Stroke. 2004 Nov;35(11):2438-43