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POSTER1
HIGHLY SPECIFIC HER2-MEDIATED CELLULAR UPTAKE OF ANTIBODY-MODIFIED NANOPARTICLES IN TUMOUR CELLS

Heidrun Wartlick1, Kerstin Michaelis1, Sabine Balthasar1, Klaus Strebhardt2, Jörg Kreuter1, Klaus Langer1
1Institute of Pharmaceutical Technology / ZAFES, Biocenter, University of Frankfurt 2Department of Obstetrics and Gynecology / ZAFES, School of Medicine, University of Frankfurt

POSTER 2
LOVASTIN CHANGES PROTEIN PATTERNS IN THE BRAIN

C. Franke, G. P. Eckert, M. Meyer1,W.E. Müller
Department of Pharmacology/ZAFES, Biocenter, Johann Wolfgang Goethe-University, Frankfurt am Main
1Ciphergen Biosystems GmbH, Hanna-Vogt-Str.1, 37085 Göttingen

POSTER 3
BRAIN AVAILABILITY OF STATINS

Gunter P. Eckert1, Jan H. Keller2, Claudia C. Weber1, Cornelia Franke1, Imke Peters1, Michael Karas2, Manfred Schubert-Zsilavecz2, Walter E. Müller1
1Dept. of Pharmacology/ZAFES & 2Dept. of Pharmaceutical Chemistry/ZAFES, Johann Wolfgang Goethe-University, Frankfurt am Main

POSTER 4
Reduced quantity of circulating Endothelial Progenitor Cells (cEPC) in patients with systemic sclerosis

Frank Behrens1, Andrea Himsel1, Stefanie Y. Zimmermann2, Stefanie Dimmeler3, J. Peter Kaltwasser1, Burkhard Möller4
1Department of Rheumatology/ZAFES, 2Paediatric Haematology/Oncology/ZAFES, 3Molecular Cardiology, Johann Wolfgang Goethe-Universität, Frankfurt 4Department of Rheumatology, Inselspital, University Berne, Switzerland

POSTER 5
IL-18 Promoter Single Nucleotide Polymorphisms in Rheumatoid Arthritis: Definition of the genetic background in future clinical trials

Noriko Koyama1, Heiko Mühl2, J Alastair Gracie3, Burkhard Möller4
1Rheumatology/Haematology/ZAFES, 2General Pharmacology & Toxocology/ZAFES Johann Wolfgang Goethe-Universität, Frankfurt am Main, 3Royal Infirmary Glasgow, UK, 4Isle University-Hospital Berne, CH

POSTER 6
Evidence of regulatory effects of peripheral T-cells on IFNg and IL-10 production of synovial tissue cells in rheumatoid arthritis

Frank Behrens1, Björn Beutel1, Stefanie Y. Zimmermann2, J. Peter Kaltwasser1, Burkhard Möller4, Heinfried H Radeke3
1Department of Rheumatology/ZAFES, 2Paediatric Haematology/Oncology/ZAFES,
3Immune Pharmacology pharmazentrum/ZAFES, Johann Wolfgang Goethe-Universität, Frankfurt, 4Department of Rheumatology, Inselspital, University Berne, Switzerland,

POSTER 7
COMPARISON OF THE CYTOTOXICITY OF TREOSULFAN AND BUSULFAN
AGAINST MALIGNANT CELLS

Munkelt D, Quaritsch R, El Kaläaoui R, Zimmermann S, Esser R, Grohal S, Rohrbach E, Klingebiel T, Köhl U University Hospital Frankfurt, Pediatric Hematology, Oncology and Hemostaseology/ZAFES, J.W.G.-University, Frankfurt, Germany

POSTER 8
DISSOLUTION METHODS TO PREDICT SITE-SPECIFIC RELEASE OF ANTI-INFLAMMATORY DRUGS IN THE GASTROINTESTINAL TRACT

Sandra Klein, Jennifer B. Dressman
Institute of Pharmaceutical Technology / ZAFES, Johann Wolfgang Goethe University, Frankfurt am Main

POSTER 9
PPAR_ AS A KEY TARGET FOR CHEMOPREVENTIVE ACTIONS OF NATURAL
OCCURING POLYPHENOLS

Sandra Ulrich, Dr. Freya Wolter, Stefan Loitsch, Prof. Dr. Dr.Jürgen Stein
Medizinische Klinik II, Johann Wolfgang Goethe-Universität, Frankfurt am Main / ZAFES

POSTER 10
Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis in the rat

Oliver Schröder1, Mattias Sjöström2, Jürgen Stein1, Per-Johann Jakobsson2, Wolfgang F. Caspary1, Jesper Z. Haeggström2
1IInd Department of Internal Medicine/ZAFES, Johann Wolfgang Goethe-University, Frankfurt/Germany, 2 MBB, Karolinska Institute, Stockholm/Sweden

POSTER 11
EINFLUSS VON STATINEN AUF DIE ZEREBRALE AUTOREGULATION BEI SUBKORTIKALER VASKULÄRER ENZEPHALOPATHIE

Dr. Matthias Lorenz, Dr. Philipp Sterzer, PD Dr. Matthias Sitzer, Prof. Dr. Helmuth Steinmetz
Neurologische Klinik/ZAFES, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main

POSTER 12
COX-dependent and –independent anticarcinogenic mechanisms of NSAIDs

Sabine Grösch, Thorsten J. Maier, Karin Schilling, Astrid Jansen, Susanne Schiffmann, Gerd Geisslinger pharmazentrum frankfurt /ZAFES,Institut für klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt/M.

POSTER 13
COX-INDEPENDENT EFFECTS OF THE COX-2-SELECTIVE INHIBITORS CELECOXIB AND ROFECOXIB

Ellen Niederberger, Christine Manderscheid, Irmgard Tegeder, Gerd Geisslinger
pharmazentrum frankfurt/ ZAFES, Institut für Klinische Pharmakologie, Johann Wolfgang Goethe-Universität, Frankfurt am Main

POSTER 14
The role of cGMP and PKG-I in spinal nociceptive processing

Achim Schmidtko1, Irmgard Tegeder1, Domenico Del Turco2, Thomas Deller2, Franz Hofmann3, Peter Ruth4, Ellen Niederberger1, Gerd Geisslinger1 1pharmazentrum frankfurt, Institut für Klinische Pharmakologie / ZAFES and 2Institut für Klinische Neuroanatomie, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main; 3Institut für Pharmakologie und Toxikologie, Technische Universität, München; 4Pharmakologie und Toxikologie, Pharmazeutisches Institut, Universität Tübingen

POSTER 15
k-MED – Knowledge-Based Multimedia Medical Education

Pharmazentrum Frankfurt, Institut für Klinische Pharmakologie/ZAFES, Johann Wolfgang Goethe-Universität, Frankfurt am Main

POSTER 16
PLATELET-LEUKOCYTE AGGREGATES AND LEUKOCYTE ACTIVATION AS TARGET OF THE P2Y12-INHIBITOR CLOPIDOGREL

Jochen Graff, Ute Klinkhardt & Sebastian Harder
pharmazentrum frankfurt, Institut für Klinische Pharmakologie/ZAFES Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main

POSTER 17
SENSITIVE DETERMINATION OF PROSTANOIDS BY LC/MS/MS

R. Schmidt, O. Coste and G. Geisslinger
pharmazentrum frankfurt/ZAFES,Institut für Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main

POSTER 18
FREEZE LESION: EXPERIMENTAL HUMAN MODEL OF INFLAMMATORY PAIN

Kosta Altis, Maria Burian, Maurizio Podda*, Lucas Kreisel*, Katya Hardt-Weinelt*, Roland Kaufmann* and Gerd Geisslinger
pharmazentrum frankfurt / ZAFES, Institut für Klinische Pharmakologie, *Klinik für Dermatologie, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main, Germany

POSTER 19
A new target in pain and inflammation:
PAM mediates inhibition of cAMP signaling by Sphingosine-1-Phosphate

Sandra Pierre, Gerd Geisslinger, Klaus Scholich
pharmazentrum frankfurt/ZAFES, Institut für Klinische Pharmakologie, Schmerzplattform Frankfurt*
Johann Wolfgang Goethe-Universität, Frankfurt am Main

POSTER 20
SENSITIVE DETERMINATION OF SELECTIVE COX-2 INHIBITORS BY LC-MS/MS

Helmut Schmidt, Anja Schmidt, Ronald Schmidt, Maic Seegel, Lutz Bräutigam, Gerd Geisslinger
pharmazentrum frankfurt/ZAFES, Institut für Klinische Pharmakologie,Theodor-Stern-Kai 7, 60590 Frankfurt am Main

POSTER 21
MU-OPIOID RECEPTOR POLYMORPHISMS AFFECTING OPIOID THERAPY

Jörn Lötsch, Carsten Skarke, Bruno Oertel, Anja Kirchhof, Philipp Kahler, Maren Rohrbacher, and Gerd Geisslinger
pharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe-University Frankfurt am Main

POSTER 22
Rescue of COX-2 dependent renal dysgenesis by EP receptor ligands

Rolf M. Nüsing, Andreas Herud, Christian Breitbarth, Anika Schuster, Antje Treude
pharmazentrum frankfurt/ZAFES, Institut für Klinische Pharmakologie, Johann Wolfgang Goethe-Universität,
Frankfurt am Main

POSTER 23
Hyperforin: Discovery of a novel antiinflammatory natural compound

Feißt, C.; Albert, D.; Steinhilber, D.; Werz, O.
Institute of Pharmaceutical Chemistry/ZAFES, Johann Wolfgang Goethe-University, Marie-Curie-Str. 9, D-60439 Frankfurt, Germany

POSTER 24
INHIBITION OF 5-LIPOXYGENASE:
NOVEL ASPECT FOR THE DEVELOPMENT OF NONREDOX-TYPE INHIBITORS

Fischer, L.§, Szellas, D.§, Rådmark, O.*, Steinhilber, D.§, and Werz, O§.
§ Institute of Pharmaceutical Chemistry/ZAFES, Johann Wolfgang Goethe-University, Frankfurt, Germany
*Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

POSTER 25
AEROSOLIZED IL-10 ATTENUATES BAL-LEVELS OF PROINFLAMMATORY CYTOKINES IN ENDOTOXEMIC RATS

Christian Hofstetter1, Michael Flondor1, Heiko Muehl2 and Bernhard Zwissler1
1Clinic for Anesthesiology, Intensive Care Medicine and Pain Therapy / ZAFES and 2Pharmazentrum Frankfurt / ZAFES, University of Frankfurt

POSTER 26
PROSTANOIDS IN PULMONARY HYPERTENSION

Christian Hofstetter, Oliver Habler, Michael Flondor and Bernhard Zwissler
Clinic for Anesthesiology, Intensive Care Medicine and Pain Therapy / ZAFES, University of Frankfurt

POSTER 27
SAFETY AND EFFICACY OF A NEW JET NEBULISER
FOR AEROLIZATION AND DRUG DELIVERY IN THE VENTILATED RAT

Christian Hofstetter, Michael Flondor, Sandra Hoegl and Bernhard Zwissler Clinic for Anesthesiology, Intensive Care Medicine and Pain Therapy / ZAFES, University of Frankfurt

POSTER 28
Influence of Inhaled and Intravenously Applied Lidocaine on the Inflammatory Reaction of the Lung in the Endotoxemic Rat

Michael Flondor, Christian Hofstetter, Holger Listle, Bernhard Zwissler Department of Anesthesiology, Intensive Care Medicine and Pain Control/ZAFES, Johann Wolfgang Goethe-Universität, Frankfurt am Main, ZAFES

POSTER 29
Sequence specific inhibition of MCP-1 gene transcription
by intracellular generated TFOs as a new gene therapeutic approach

K. Kautz, M. Schwarz, H.H. Radeke
Dr.-Schleussner-Foundation Immune Pharmacology/ZAFES, pharmazentrum frankfurt/ZAFES, Clinic of the J.W. Goethe University, D-60590 Frankfurt

POSTER 30
Generation of chemokine receptor antagonists to block T helper-1 lymphocyte mediated inflammation

S. Rubant, M. Schwarz, J. Pfeilschifter, H.H. Radeke
Dr.-Schleussner-Foundation Immune Pharmacology/ZAFES, pharmazentrum frankfurt/ZAFES, Clinic of the J.W. Goethe University, D-60590 Frankfurt

POSTER 31
CYCLOSPORINE A-AND RAPAMYCIN INHIBIT CYTOKINE-INDUCED MATRIX-METALLOPROTEINASE-9 (MMP-9) EXPRESSION IN MESANGIAL CELLS

Vernea Ulbricht, El-Sayed Akool,Christine Kurowski, Henriette Rau, Roswitha Müller, Josef Pfeilschifter and Wolfgang Eberhardt pharmazentrum frankfurt/ZAFES, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt am Main

POSTER 32
Nonsteroidal anti-inflammatory drugs for therapy of Epstein Barr virus-associated Burkitt´s lymphoma

Eva-Maria Westphal, Monika Bayer, Josef Pfeilschifter
Institute of General Pharmacology and Toxicology/ZAFES, Johann Wolfgang Goethe-University, Frankfurt am Main

POSTER 33
Sphingosine-1-phosphate mimics TGFb-induced cell responses in renal mesangial cells and may exert anti-inflammatory potential

Andrea Huwiler, Cuiyan Xin, Shuyu Ren, Burkhardt Kleuser, Soheyla Shabahang, Wolfgang Eberhardt, Heinfried Radeke, Monika Schäfer-Korting and Josef Pfeilschifter Pharmazentrum Frankfurt/ZAFES, Klinikum der Johann Wolfgang Goethe-Universität, Frankfurt am Main

POSTER 34
HISTAMINE DERIVATIVES AS POTENTIAL NMDA RECEPTOR LIGANDS

P.P. Griffin1, S. Graßmann2, U. Reichert2, C. Bayard3, J.-M. Arrang3, J.-C. Schwartz3, W. Schunack2, H. Stark1
1Johann Wolfgang Goethe-Universität, Biozentrum/ZAFES, Institut für Pharmazeutische Chemie, Marie-Curie-Str. 9, 60439 Frankfurt, E-mail: H.STARK@ZAFES.de; 2 Freie Universität Berlin, Institut für Pharmazie, Königin-Luise-Str. 2+4, 14195 Berlin, Germany; 3Unité de Neurobiologie et Pharmacologie Moléculaire, Centre Paul Broca de I’INSERM, 2ter rue d’Alésia, 75014 Paris, France.

POSTER 35
DRUG DEVELOPMENT WITH NEW LEADS IN HISTAMINE H3 RECEPTOR ANTAGONISTS

Michael Amon1, Tibor Miko2, Xavier Ligneau3, Heinz H. Pertz2, C. Robin Ganellin4,
Jean-Michel Arrang5, Jean-Charles Schwartz3,5, Walter Schunack2, Holger Stark1*
1*Johann Wolfgang Goethe-Universität, Biozentrum/ZAFES, Institut für Pharmazeutische Chemie, Marie-Curie-Strasse 9, 60439 Frankfurt, E-mail: H.STARK@ZAFES.DE
2Freie Universität Berlin, 14195 Berlin; 3Bioprojet Biotech, BP 96205, 35762 Saint Grégoire Cedex, France; 4University College London, London WC1H OAJ, U.K.;
5Unité de Neurobiologie et Pharmacologie Moléculaire de I‘INSERM, 75014 Paris, France;

POSTER 36
DRUG DEVELOPMENT WITH NEW LEADS IN DOPAMINE D2/3 RECEPTOR LIGANDS

H. Kubas1, U. Mach1, C.G. Wermuth2, J.-C. Schwartz3, S. Ferry4, P. Sokoloff4, H. Stark1.
1 Johann Wolfgang Goethe-Universität, Biozentrum/ZAFES, Institut für Pharmazeutische Chemie, Marie-Curie-Str. 9, 60439 Frankfurt, E-mail: H.STARK@ZAFES.DE;
2 Faculté de Pharmacie (CNRS), 74 route de Rhin, 67401 Illkirch, France;
3 Bioprojet-Biotech, 4 rue du Chesnay Beauregard, 35762 Saint-Grégoire, France;
4 INSERM, 2ter rue d’Alésia, 75014 Paris, France.

POSTER 37
Design of CpG-Oligodesoxynucleotides for asthma therapy

Gerda Wittel, Dr. Ping Gu, Prof. Dr. J. W. Engels
Institut für Organische Chemie und Chemische Biologie/ZAFES, Johann Wolfgang Goethe-Universität, Frankfurt am Main

POSTER 38
Inhibitors of the soluble epoxide hydrolase (sEH) increase the biological actions of EETs and are potent antihypertensive agents

Alexandra Rueben, Rüdiger Popp, Oliver Jung, Ralf P. Brandes, Rudi Busse, Ingrid Fleming
Institut für Kardiovaskuläre Physiologie/ZAFES, Johann Wolfgang Goethe-Universität, Frankfurt am Main

POSTER 39
Sulfaphenazole attenuates oxidative stress in isolated coronary arteries and in patients with coronary artery disease

Ingrid Fleming, U. Ruth Michaelis, Ralf P. Brandes, Rudi Busse
Institut für Kardiovaskuläre Physiologie/ZAFES, Johann Wolfgang Goethe-Universität, Frankfurt am Main

POSTER 40
ACE-inhibitors enhance COX-2 expression and prostacyclin production in endothelial cells via ACE-dependent outside-in signalling

K. Kohlstedt, R. Busse, I. Fleming
Vascular Signaling Group, Johann Wolfgang Goethe-Universität, Frankfurt am Main

POSTER 41
GENERATION OF MONOCLONAL ANTIBODIES TO SECONDARY PLANT METABOLITES

Dr. Ilse Zündorf, Christian Klein, Prof. Dr. Theodor Dingermann
Institute of Pharmaceutical Biology/ZAFES, Biocenter, Johann Wolfgang Goethe-University, Frankfurt /Main

POSTER 42
TARGETED INTEGRATION OF DICTYOSTELIUM RETROTRANSPOSONS: CONCEPT FOR SAFER GENE TRANSFER VECTORS

PD Dr. Thomas Winckler, Oliver Siol, Thanh Chung, Prof. Dr. Theodor Dingermann
Institut für Pharmazeutische Biologie/ZAFES, Biocenter, Johann Wolfgang Goethe-University, Frankfurt / Main

POSTER 43
INTERACTION OF AF4 WILDTYPE AND AF4•MLL FUSION PROTEIN WITH SIAH PROTEINS: INDICATION FOR T(4;11) PATHOBIOLOGY

Adelheid Bursen, Sven Moritz, Anne Gaussmann, Prof. Dr. Theo Dingermann & Prof. Dr. Rolf Marschalek
Institute of Pharmaceutical Biology/ZAFES, Biocenter, Johann Wolfgang Goethe-University, Frankfurt / Main

POSTER 44
A NEW DIAGNOSTIC TOOL FOR THE IDENTIFICATION OF MLL REARRANGEMENTS INCLUDING UNKNOWN PARTNER GENES

Claus Meyer1, Björn Schneider1, Martin Reichel2, Sieglinde Angermüller2, Sabine Strehl3, Susanne Schnittger4, Claudia Schoch4, Mieke W.J.C. Jansen5, Jacques J. van Dongen5, Rob Pieters6, Oskar A. Haas3, Theo Dingermann1, Thomas Klingebiel7, and Rolf Marschalek1
Institute of Pharmaceutical Biology/ZAFES, Biocenter, Johann Wolfgang Goethe-University, Frankfurt / Main

POSTER 45
EFFECTS OF SEVEN ANTI-EPILEPTIC DRUGS ON EXCITABILITY
OF HUMAN MOTOR CORTEX

S. Benilow, H. Alle, K.Krakow, U. Ziemann
Clinic of Neurology/ZAFES, Johann Wolfgang Goethe University, Frankfurt am Main

POSTER 46
Determination of KBA and AKBA in brain and human plasma

Reising K.1, Meins J.1, Bastian B.1 ,Schubert-Zsilavecz M.1,2, Abdel Tawab M.1 1Central laboratory of German pharmacists/ZAFES, Eschborn, 2 Institute of Pharmaceutical Chemistry/ZAFES,
Johann Wolfgang Goethe University, Frankfurt am Main

POSTER 47
PPAR: Ligands, Three-dimensional structures, molecular interactions and pharmacological implications

Yvonne Syha, Laura Popescu, Oliver Rau, Manfred Schubert-Zsilavecz Institute of Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Frankfurt am Main

POSTER 48
Virtual Screening For COX-2 / 5-LO Dual Inhibitors

L. Franke, G. Schneider
Institut für Organische Chemie und Chemische Biologie/ZAFES, Johann Wolfgang Goethe-Universität, Frankfurt am Main

POSTER 49
HYPERFORIN ACTIVATES NON SELECTIVE CATION CHANNELS

Kristina Treiber, Bettina Henke, Andrea Singer, and Prof. Dr. W.E. Müller
Pharmakologisches Institut für Naturwissenschaftler, Johann Wolfgang Goethe-Universität, Frankfurt am Main

POSTER 50
HYPERFORIN ACTIVATES NON SELECTIVE CATION CHANNELS

Kristina Treiber, Bettina Henke, Andrea Singer, and Prof. Dr. W.E. Müller
Pharmakologisches Institut für Naturwissenschaftler, Johann Wolfgang Goethe-Universität, Frankfurt am Main

POSTER 51
P38 MAPK signaling pathway is involved in butyrate-induced vitamin D receptor expression

Carolin Daniel, Oliver Schröder, Nadine Zahn, Tanja Gaschott, W.F. Caspary and Jürgen Stein
2nd Department of Medicine/ZAFES, Johann Wolfgang Goethe University, Frankfurt/Main

POSTER 52
Immunomodulating therapy in experimental colitis. Th1/Th2-switch by 1,25-Dihydroxyvitamin D3 in corticosteroid-treated mice

Carolin Daniel1, Heinfried H. Radeke2, Wolfgang F. Caspary1 and Jürgen Stein1
12nd Department of Medicine, 2pharmazentrum/ZAFES, Johann Wolfgang Goethe University, Frankfurt/Main

POSTER 53
Correlation between Genomic and MR-Spectroscopic Findings in Glioblastomas: Amplification of the Gene for the Epidermal Growth Factor Receptor (EGFR)

R. Nafe, W. Glienke, E. Hattingen, S. Herminghaus, U. Pilatus, W. Schlote, H. Lanfermann, F. Zanella
Dept. Neuroradiology, Dept. Hematology, Dept. Neuropathology - Clinics of Johann Wolfgang Goethe-University, Frankfurt / Main

POSTER 54
In vivo Proton MR Spectroscopy for Grading of Glioma and Monitoring Therapy

E. Hattingen, U. Pilatus, K. Franz, H. Lanfermann, F.E. Zanella
Institut für Neuroradiologie/ZAFES, Johann Wolfgang Goethe-Universität, Frankfurt am Main

POSTER 55
VISUALISATION OF INTEGRITY AND CONNECTIVITY
OF WHITE MATTER FIBER TRACTS

C. Lienerth, E. Hattingen, H. Lanfermann, F. E. Zanella
Brain Imaging Center/ZAFES, Johann Wolfgang Goethe-Universität, Frankfurt am Main

POSTER 56
Paul-Ehrlich-Institut
Division 6: Medical Biotechnology

Christian J. Buchholz, Egbert W.A. Flory, Matthias Schweizer, Ralf R. Tönjes
Head: Klaus Cichutek, cickl@pei.de
Paul-Ehrlich-Strasse 51-59, D-63225 Langen/Hessen

 


 

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